Lindsay S. Shaffer

Lindsay S. Shaffer

Lindsay S. Shaffer

Graduate Research Assistant

Cognitive and Behavioral Neuroscience: computational neuroscience, electrophysiology, neuroimaging, psychosis, reward processing

My name is Lindsay Shaffer and I'm a 3rd year PhD student in the CBN program. My advisor is Dr. Jim Thompson. I am also a NSF NRT Fellow through the Center for Adaptive Systems of Brain-Body Interactions (CASBBI).

My research primarily focuses on understanding the pathophysiology of psychotic disorders. I am particularly interested in studying systemic approaches to reward processing, such as how sensory and value information converge together within the brain, because of the high prevalence of reward deficits in these diseases.

My approach is three-fold:

  1. utilizing behavioral paradigms and computational modeling to provide quantitatively meaningful information about clinical phenomena;
  2. incorporate various recording modalities of brain activity such as fMRI, EEG, and eye-tracking;
  3. compare how psychotic symptoms manifest in other diseases, such as Parkinson's disease, which have overlapping pathophysiologies with schizophrenia (e.g., dopamine dysregulation).

I'm also strongly interested in efforts improving patient outcomes and precision medicine initiatives. As a part of my NSF NRT Fellowship, I'm currently collaborating with members of the S.T.A.R. Lab, the Biomedical Imaging Lab, the Michael J. Fox Foundation, the INOVA Parkinson's and Movement Disorders Clinic, and Vibrent Health to develop a novel application that can remotely measure symptoms in Parkinson's disease and share collected information with the patient's clinical care team.

Selected Publications

Sedlak TW, Nucifora LG, Koga M, Shaffer LS, Higgs C, Tanaka T, Wang AM, Coughlin JM, Barker PB, Fahey JW, Sawa A. Sulforaphane augments glutathione and influences brain metabolites in human subjects: A clinical pilot study. Mol Neuropsychiatry. 2018 May;3(4):214-222.

Mills EW, Shaffer LS, Goes FS, Sawa A, Nucifora FC Jr. Case of secondary tics associated with olanzapine in an adult. Front Psychiatry. 2017 Aug 15;8:150.

Grants and Fellowships

CASBBI National Science Foundation (NSF) NRT Fellowship (2020; Sponsor: NSF)

Education

B.A., Psychology - University of Maryland Baltimore County (UMBC)